Daily orange juice may boost heart health—but weight changes the benefits

A new study suggests that drinking orange juice regularly could benefit heart health. Researchers found that moderate, long-term consumption may help regulate blood pressure, reduce inflammation, and improve lipid levels. The effects, however, vary depending on a person's weight.

The study tracked participants who drank 500 ml of orange juice daily for 60 days. Over this period, the activity of 1,705 genes in their bodies changed. In people of normal weight, the most noticeable shifts occurred in genes linked to inflammation and immune function.

For overweight individuals, the juice had a different impact. Their gene activity changes were mainly tied to lipid metabolism and fat tissue formation. The drink also influenced dozens of microRNAs and other non-coding RNAs, which play roles in regulating various bodily processes.

Researchers noted that these findings could support more tailored dietary advice. Foods rich in flavonoids, like orange juice, might one day be recommended based on individual health profiles.

The results highlight how orange juice affects the body differently depending on weight. While it may improve cardiovascular markers, the specific benefits shift between normal-weight and overweight people. Further research could refine how such drinks fit into personalized nutrition plans.